Synthetic Glycobiology: Engineering Custom Glycans for Therapeutic Applications
Glycosylation, the enzymatic attachment of sugar moieties (glycans) to proteins and lipids, is a fundamental post-translational modification that profoundly influences a wide array of biological processes, including protein folding, cell-cell recognition, immune responses, and pathogen-host interactions. The immense structural diversity of glycans translates into a complex 'glycocode' that