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Echocardiography-Guided Cryoablation: Using Real-Time Ultrasound Imaging to Control Ice Ball Formation and Minimize Collateral Tissue Damage During Cardiac Arrhythmia Treatment

Echocardiography-Guided Cryoablation: Using Real-Time Ultrasound Imaging to Control Ice Ball Formation and Minimize Collateral Tissue Damage During Cardiac Arrhythmia Treatment

Cryoballoon ablation has become a cornerstone therapy for atrial fibrillation (AF), offering a durable and efficient method for electrically isolating the pulmonary veins (PVs), the primary source of aberrant signals in many patients. The procedure's success hinges on creating transmural, lasting lesions by applying freezing temperatures to the

Radiolytic Degradation of Pharmaceuticals in Deep Space: Developing Novel Excipients and On-Demand Synthesis Platforms to Ensure Crew Health on Long-Duration Missions

Radiolytic Degradation of Pharmaceuticals in Deep Space: Developing Novel Excipients and On-Demand Synthesis Platforms to Ensure Crew Health on Long-Duration Missions

As humanity stands on the precipice of becoming a multi-planetary species, with crewed missions to Mars and beyond transitioning from science fiction to concrete engineering roadmaps, we must confront the immense challenge of ensuring human health far from Earth. A three-year mission to Mars will be the longest and most

All-Optical Microfluidics: Leveraging Photothermal Effects to Create Reprogrammable, Non-Invasive Virtual Valves and Pumps for High-Throughput Single-Cell Analysis.

All-Optical Microfluidics: Leveraging Photothermal Effects to Create Reprogrammable, Non-Invasive Virtual Valves and Pumps for High-Throughput Single-Cell Analysis.

Conventional microfluidic systems, the "lab-on-a-chip" technologies that underpin much of modern biology and chemistry, rely on a hardware-based paradigm. Their channels, mixers, valves, and pumps are physically etched into materials like glass or PDMS, creating a fixed and immutable architecture. This approach, while powerful, suffers from inherent limitations:

Tomographic Volumetric Additive Manufacturing: Using Spatiotemporally Sculpted Light to Solidify an Entire Volume of Photopolymer Resin at Once, Enabling Support-Free, Millisecond-Scale 3D Fabrication.

Tomographic Volumetric Additive Manufacturing: Using Spatiotemporally Sculpted Light to Solidify an Entire Volume of Photopolymer Resin at Once, Enabling Support-Free, Millisecond-Scale 3D Fabrication.

Conventional 3D printing, or additive manufacturing (AM), has fundamentally changed prototyping and manufacturing by building objects layer-by-layer. However, this sequential approach suffers from inherent limitations: it is often slow, requires extensive support structures for complex geometries, and introduces anisotropic mechanical properties due to the layered interfaces. A revolutionary new paradigm,

Generative AI for De Novo Protein Design: From Latent Space to Laboratory

Generative AI for De Novo Protein Design: From Latent Space to Laboratory

The ability to design proteins from first principles—'de novo' design—represents a grand challenge in biotechnology and medicine. For decades, scientists have sought to create bespoke proteins tailored for specific functions, from high-affinity therapeutics to novel industrial enzymes. This endeavor, however, has been profoundly difficult, limited by

Axion Haloscopes as a Probe for Dark Matter: Using Resonant Microwave Cavities in High Magnetic Fields to Detect the Conversion of Galactic Axions into Photons

Axion Haloscopes as a Probe for Dark Matter: Using Resonant Microwave Cavities in High Magnetic Fields to Detect the Conversion of Galactic Axions into Photons

The existence of dark matter is one of the most profound puzzles in modern physics, inferred from its gravitational effects on galaxies and the large-scale structure of the universe, yet its composition remains unknown. Among the leading candidates is the axion, a hypothetical elementary particle originally proposed to solve the

Sonocatalytic Degradation of Per- and Polyfluoroalkyl Substances (PFAS): Leveraging Acoustic Cavitation to Break Strong Carbon-Fluorine Bonds in Environmental Remediation

Sonocatalytic Degradation of Per- and Polyfluoroalkyl Substances (PFAS): Leveraging Acoustic Cavitation to Break Strong Carbon-Fluorine Bonds in Environmental Remediation

Per- and polyfluoroalkyl substances (PFAS) represent a class of thousands of synthetic chemicals characterized by chains of carbon atoms saturated with fluorine atoms. The carbon-fluorine (C-F) bond is one of the strongest in organic chemistry, granting these compounds exceptional thermal and chemical stability. This has made them invaluable in a