Terahertz-frequency Opto-mechanical Metasurfaces for Real-time Monitoring of Conformational Dynamics in Intrinsic Disordered Proteins (IDPs) during Liquid-Liquid Phase Separation
Intrinsically disordered proteins (IDPs) challenge the traditional structural biology paradigm by functioning seamlessly without a fixed three-dimensional conformation. Under specific physiological conditions, these highly dynamic macromolecules undergo liquid-liquid phase separation (LLPS), assembling into dense biomolecular condensates. This phase transition is critical for spatial organization within the cell, regulating complex operations