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Designer Glycans: Engineering Novel Carbohydrate Structures for Precision Therapeutics

Designer Glycans: Engineering Novel Carbohydrate Structures for Precision Therapeutics

Carbohydrates, or glycans, are fundamental to virtually every biological process, mediating cell recognition, signaling, and structural integrity. Despite their ubiquity and importance, the intricate complexity of glycans has historically posed challenges for their precise manipulation and therapeutic application. Traditional therapeutics often overlook the profound impact of glycosylation, or suffer from
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Computational Archaeolinguistics: Reconstructing Proto-Languages with AI Language Models

Computational Archaeolinguistics: Reconstructing Proto-Languages with AI Language Models

Archaeolinguistics, the study of the deep history of languages, strives to reconstruct proto-languages—the hypothetical ancestral tongues from which documented language families evolved. This endeavor has traditionally relied on the meticulous, labor-intensive comparative method, supplemented by lexicostatistics and more recently, computational phylogenetic approaches. However, the sheer scale of linguistic data,
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Self-Healing Organometallic Nanocomposites for Resilient Aerospace Structures in Hypersonic Regimes

Self-Healing Organometallic Nanocomposites for Resilient Aerospace Structures in Hypersonic Regimes

Hypersonic flight, characterized by speeds exceeding Mach 5, imposes unprecedented thermal, mechanical, and chemical stresses on aerospace structures. The extreme temperatures, rapid thermal cycling, high heat fluxes, and oxidative environments encountered can lead to material degradation, micro-cracking, and ultimately, structural failure. Traditional aerospace materials, while robust, often lack the ability